Intestinal flora maintains the intestinal mucosal barrier and interacts with the immune system. It plays an important role in human metabolism, and its metabolites affect different tissues and organs. Gut microbiota is a microecosystem composed of various microorganisms. This could be particularly relevant for patients with intermediate MELD-scores, who have limited chances for a donor liver. Importantly, the prognosis remains unfavorable even after resolution of nSBP. While a current as well as a resolved nSBP were significantly linked to a higher mortality, neither of them did increase the likelihood for liver transplantation.ĭevelopment of nSBP is independently associated with increased mortality supporting the concept of a distinct status of cirrhosis. Again, this was only significant in those with intermediate MELD-scores (p = 0.02 HR = 2.28).

Importantly, mortality in nSBP patients remained increased even after the initial nSBP episode had resolved (p<0.01 HR = 1.90).

However, the most prominent difference in mortality was documented in the intermediate MELD-group (nSBP: p = 0.02 HR = 2.10). Mortality was significantly higher in patients with nosocomial-acquired SBP (nSBP) compared to patients without SBP (p<0.001 HR = 2.05). Statistical analyses were performed using the log-rank test, Cox regression and competing risk analysis. MELD-score was used to determine the stage of liver disease. In this study we aimed to further analyze the impact of a current as well as a resolved SBP in different stages of decompensated liver cirrhosis.Ī number of 579 patients with liver cirrhosis and ascites were included. Moreover, if there is such a distinct stage, it must be determined whether it is reversible after the infection has resolved. However, it remains unclear whether all stages of decompensated cirrhosis are equally affected. Onset of infection was suggested to define a distinct stage of cirrhosis. Recently, it has been shown that the impact on mortality might be underestimated by established risk-scores. New options for visualizing scatter plots.Bacterial infections, in particular a spontaneous bacterial peritonitis (SBP), are a major threat in patients with liver cirrhosis.Introducing new features, performance improvements and bug fixes for Prism 8, including:

Graphpad prism 7 el capitan